RNA Biology Publications | MAGE Lab Liège

Articles in journals

Last/Co-last author

Intrinsic disorder and salt-dependent conformational changes of the N-terminal region of TFIP11 splicing factor

Juniku B., Mignon J., Carême R., Genco A., Obeid A.M., Mottet D.*, Monari A*., Michaux C*.

International Journal of Biological Macromolecules, (2024)

*Authors contributed equally

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Non-canonical role for the BAF complex subunit in mitosis and ciliogenesis

Verrillo G., Obeid A.M., Genco A., Scrofani J., Ornage F., Hanache S., Mignon J., Leyder T., Michaux C., Kempeneers C., Bricmont N., Herkenne S., Vernos I., Martin M., Mottet D.

Journal of Cell Science, (2024)

Publication highlighted by Journal’s editor :

https://journals.biologists.com/jcs/article/137/9/e137_e0902/347315/A-new-role-for-the-BAF-complex-subunit-DPF3-in

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Poly(N-methyl-N-vinylacetamide): A Strong Alternative to PEG for Lipid-Based Nanocarriers Delivering siRNA

Berger M., Toussaint F., Ben Djemaa S., Maquoi E., Pendeville H., Evrard B., Jerôme C., Leblong Chain J., Lechanteur A., Mottet D.*, Debuigne A*., Piel G*.

Advanced Healthcare Materials, (2023)

*Authors contributed equally

Publication selected for the journal's cover

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Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery

Berger M., Toussaint F., Ben Djemaa S., Laloy J., Pendeville H., Evrard B., Jerôme C., Lechanteur A., Mottet D.*, Debuigne A*., Piel G*. Journal of Controlled Release, (2023)

*Authors contributed equally

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DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

Duchemin A., O’Grady T., Hanache S., Mereau A., Thiry M., Wacheul L., Michaux C., Perpète E.A., Hervouet E. Peixoto P., Ernst F.G.M., Audic Y., Dequiedt F., Lafontaine D.J., Mottet D. Nature Communications, (2021)

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Metabolic inhibitors accentuates the anti-tumoral effect of HDAC5 inhibition

Hendrick E., Peixoto P., Blomme A., Polese C., Mathéus N., Cimino J., Frère A., Mouithys-Mickalad A., Serteyn D., Bettendorff L., Elmoualij B., De Tullio P., Eppe G., Dequiedt F., Castronovo V., Mottet D. Oncogene, (2017)

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PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy

Frere A., Kawalec M., Tempelaar S., Peixoto P., Hendrick E., Peulen O., Dakwar GR., Diricq J., Dubois P., Evrard B., Remaut K., Braeckmans K., De Smedt SC., Laloy J., Dogné JM., Feller G., Mespouille L., Mottet D*., Piel G*. *Authors contributed equally ACS Appl Mater Interfaces, (2017)

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Impact of the structure of biocompatible aliphatic polycarbonates on siRNA transfection ability

Frere A., Kawalec M., Tempelaar S., Peixoto P., Hendrick E., Peulen O., Evrard B., Dubois P., Mespouille L*., Mottet D*., Piel G*. *Authors contributed equally Biomacromolecules, (2015)

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A new role for HDAC5 in the maintenance of long telomeres

Lopes Novo C., Polese C., Matheus N., Decottignies A., Londono-Vallejo A., Castronovo V., Mottet D., FASEB J., (2013)

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HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell cycle progression and survival of human cancer cells

Peixoto P., Castronovo V., Matheus N., Polese C., Peulen O., Gonzalez G., Boxus M., Verdin E., Thiry M., Dequiedt F., Mottet D., Cell Death and Differentiation, (2012)

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1^stand co-1^st author

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance

Kasler HG.*, Lim HW.*, Mottet D.*, Collins AM., Lee IS., Verdin E., *Authors contributed equally Embo J., (2012)

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The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells

Turtoi A. *, Mottet D. *, Matheus N., Dumont B., Peixoto P., Hennequière V., Deroanne C., Colige A., De Pauw E., Bellahcène A., Castronovo V., *Authors contributed equally Angiogenesis, (2012)

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HDAC4 represses p21 (WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

Mottet D., Pirotte S., Lamour V., Hagedorn M., Javerzat S., Bikfalvi A., Bellahcene A., Verdin E., Castronovo V., Oncogene, (2009)

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HDAC7 silencing alters endothelial cell migration, a key step in angiogenesis

Mottet D., Bellahcene A., Waltregny D., Deroanne C., Lamour V., Pirotte S., Lidereau R., Castronovo V., Circulation Research, (2007)

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Role for casein kinase 2 in the regulation of HIF-1 activity

Mottet D., Ruys S., Demazy C., Raes M., Michiels C., International journal of cancer, (2005)

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Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

Mottet D., Dumont V., Deccache Y., Demazy C., Ninane N., Raes M., Michiels C., Journal of Biological Chemistry, (2003)

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Role of ERK and calcium in the hypoxia-induced activation of HIF-1

Mottet D., Michel G., Renard P., Ninane N., Raes M., Michiels C., Journal of Cellular Physiology, (2003)

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ERK and calcium in activation of HIF-1

Mottet D., Michel G., Renard P., Ninane N., Raes M., Michiels C., Annual New York Academy of Sciences, (2002)

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Associated author

Unveilling the effect of phosphorylation and phosphomimetics on the structural and aggregation properties of the amyloidogenic intrinsically disordered protein DPF3a

Leyder T., Mignon J., Bongiovanni E., Machiels Q., Waeytens J., Raussens V, Monari A., Mottet D., Michaux C*. International Journal of Biological Macromolecules, (2026)

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Exploration of the influence of environmental changes on the conformational and amyloidogenic landscapes of the zinc finger protein DPF3a by combining biophysical and molecular dynamic approaches

Mignon J., Leyder T., Monari A., Mottet D., Michaux C*. International Journal of Biological Macromolecules, (2025)

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In-depth investigation of the effect of pH on the autofluorescence properties of DPF3b and DPF3a amyloid fibrils

Mignon J., Leyder T., Mottet D., Uversky V.N., Michaux C*. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, (2024)

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Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

Musawi S., Donnio L.M., Zhao Z., Magnani C., Rassinoux P., Binda O., Huang J., Jacquier A., Coudert L., Lomonte P., Martinat C., Schaeffer L., Mottet D., Côté J., Mari P.O., Giglia-Mari G., Nature Communications, (2023)

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Unveiling the metal-dependent aggregation properties of the C-terminal region of amyloidogenic intrinsically disordered protein isoforms DPF3b and DPF3a

Leyder T., Mignon J., Mottet D., Michaux C., International Journal of Molecular Sciences, (2022)

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Structural characterisation of amyloidogenic intrinsically disordered zinc finger protein isoforms DPF3b and DPF3a

Mignon J., Mottet D., Leyder T., Uversky V.N., Perpète E.A., Michaux C., International Journal of Biological Macromolecules, (2022)

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Revealing intrinsic disorder and aggregation properties of the DPF3a Zinc Finger Protein

Mignon J., Mottet D., Verrillo G., Matagne A., Perpète E.A., Michaux C., ACS Omega, (2021)

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HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts

Warnon C., Bouhjar K., Ninane N., Verhoyen M., Fattaccioli A., Fransolet M., de Rouvroit C.L., Poumay Y., Piel G., Mottet D., Debacq-Chainiaux F., Aging, (2021)

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Systematic study of liposomes composition towards efficient delivery of plasmid DNA as potential application of dermal fibroblasts targeting In vitro skin penetration enhancement techniques

Bellefroid C., Reusch C., Lechanteur A., Evrard B., Debacq-Chainiaux F., Mottet D., Piel G. International Journal of Pharmaceutics., (2021)

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Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion

Beloso A., Martin M., Bruyr J., O’Grady T., Deroanne C., Mottet D., Twizere JC., Cherrier T., Dequiedt F. Cell Death and Diseases., (2019)

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In vitro skin penetration enhancement techniques: a combined approaches of ethosomes and microneedles

Bellefroid C., Lechanteur A., Evrard B., Mottet D., Debacq-Chainiaux F., Piel G. International Journal of Pharmaceutics, (2019)

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Cationic liposomes carrying siRNA: impact of lipid composition on physicochemical properties, cytotoxicity and endosomal escape

Lechanteur A., Sanna V., Duchemin A., Evrard B., Mottet D., Piel G. Nanomaterials, (2018)

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky DJ, Mottet D., Zughaier SM, Autophagy,12(1) (2016)

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An easy, convenient cell and tissue extraction protocol for nuclear magnetic resonance metabolomics

Mathéus N., Hansen S., Rozet E., Peixoto P., Maquoi E., Lambert V., Noël A., Frédérich M., Mottet D., De Tullio P. Phytochem Anal., (2014)

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The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2

Peulen O., Gonzalez A., Peixoto P., Turtoi A., Mottet D., Delvenne P., Castronovo V. Plos One., (2013)

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PP2A regulatory subunit B controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

Martin M., Geudens I., Bruyr J., Potente M., Bleuart A., Lebrun M., Simonis N., Deroanne C., Twizere JC., Soubeyran P., Peixoto P., Mottet D., Janssens V., Hofmann WK., Claes F., Carmeliet P., Kettmann R., Gerhardt H., Dequiedt F. Embo J., (2013)

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Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2

Pirotte S., Lamour V., Lambert V., Alvarez Gonzalez ML., Ormenese S., Noël A., Mottet D., Castronovo V., Bellahcene A., Blood, (2011)

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Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes

Kasler HG., Young BD., Mottet D., Lim HW., Collins AM., Olson EN., Verdin E., Journal of Immunology, (2011)

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Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain

Michel G., Minet E., Mottet D., Remacle J., Michiels C., Biochimica Biophysica Acta, (2002)

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CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2,

Piret JP., Mottet D., Raes M., Michiels C., Annual New York Academy of Sciences, (2002)

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c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells

Minet E., Michel G., Mottet D., Piret JP., Barbieux A., Raes M., Michiels C., Experimental Cell Research, (2001)

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ERK activation upon hypoxia: involvement in HIF-1 activation

Minet E., Arnould T., Michel G., Roland I., Mottet D., Raes M., Remacle J., Michiels C., FEBS Letters, (2000)

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Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

Minet E., Mottet D., Michel G., Roland I., Raes M., Remacle J., Michiels C., FEBS Letters, (1999)

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Reviews in journals

1^st and last author

Histone deacetylases: anti-angiogenic targets in cancer therapy

Mottet D., Castronovo V., Current Cancer Drug Targets. 10 (2010), 898-913

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Histone deacetylases: a new class of anti-cancer drugs

Mottet D., Castronovo V., Med Sci (Paris). (2008)

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Histone deacetylases: target enzymes for cancer therapy

Mottet D., Castronovo V., Clin Exp Metastasis. (2008)

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Associated author

Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes

Michiels C., Minet E., Mottet D., Raes M., Free Radic Biol Med. (2002)

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Is HIF-1alpha a pro- or an anti-apoptotic protein?

Piret JP., Mottet D., Raes M., Michiels C., Biochemistry Pharmacology (2002)

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HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases

Michiels C., Minet E., Michel G., Mottet D., Piret JP., Raes M., IUBMB Life (2001)

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Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

Minet E., Michel G., Mottet D., Raes M., Michiels C., Free Radic Biol Med. (2001)

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Scientific publications

Articles in journals

Last/Co-last author

Intrinsic disorder and salt-dependent conformational changes of the N-terminal region of TFIP11 splicing factor

Non-canonical role for the BAF complex subunit in mitosis and ciliogenesis

Poly(N-methyl-N-vinylacetamide): A Strong Alternative to PEG for Lipid-Based Nanocarriers Delivering siRNA

Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

Metabolic inhibitors accentuates the anti-tumoral effect of HDAC5 inhibition

PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy

Impact of the structure of biocompatible aliphatic polycarbonates on siRNA transfection ability

A new role for HDAC5 in the maintenance of long telomeres

HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell cycle progression and survival of human cancer cells

1stand co-1st author

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance

The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells

HDAC4 represses p21 (WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

HDAC7 silencing alters endothelial cell migration, a key step in angiogenesis

Role for casein kinase 2 in the regulation of HIF-1 activity

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

Role of ERK and calcium in the hypoxia-induced activation of HIF-1

ERK and calcium in activation of HIF-1

Associated author

Unveilling the effect of phosphorylation and phosphomimetics on the structural and aggregation properties of the amyloidogenic intrinsically disordered protein DPF3a

Exploration of the influence of environmental changes on the conformational and amyloidogenic landscapes of the zinc finger protein DPF3a by combining biophysical and molecular dynamic approaches

In-depth investigation of the effect of pH on the autofluorescence properties of DPF3b and DPF3a amyloid fibrils

Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

Unveiling the metal-dependent aggregation properties of the C-terminal region of amyloidogenic intrinsically disordered protein isoforms DPF3b and DPF3a

Structural characterisation of amyloidogenic intrinsically disordered zinc finger protein isoforms DPF3b and DPF3a

Revealing intrinsic disorder and aggregation properties of the DPF3a Zinc Finger Protein

HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts

Systematic study of liposomes composition towards efficient delivery of plasmid DNA as potential application of dermal fibroblasts targeting In vitro skin penetration enhancement techniques

Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion

In vitro skin penetration enhancement techniques: a combined approaches of ethosomes and microneedles

Cationic liposomes carrying siRNA: impact of lipid composition on physicochemical properties, cytotoxicity and endosomal escape

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

An easy, convenient cell and tissue extraction protocol for nuclear magnetic resonance metabolomics

The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2

PP2A regulatory subunit B controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2

Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes

Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain

CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2,

c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells

ERK activation upon hypoxia: involvement in HIF-1 activation

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

Reviews in journals

1st and last author

Histone deacetylases: anti-angiogenic targets in cancer therapy

Histone deacetylases: a new class of anti-cancer drugs

Histone deacetylases: target enzymes for cancer therapy

Associated author

Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes

Is HIF-1alpha a pro- or an anti-apoptotic protein?

HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

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1^stand co-1^st author

1^st and last author